Mark attended Liberty College in Lynchburg, VA, from 1975 to 1980 where he first intended to gain a Business degree. In 1976, Mark felt God was calling him to a music ministry and, when he graduated in 1980 with a Youth degree, he began performing at independent Baptist churches around the country. His first booking agent, Roy Morgan, booked Mark in 43 cities in 41 days.
In 1988, Mark was offered the baritone part in the Gaither Vocal Band. Mark remained with the Vocal Band for 13 years, performing dozens of solo concerts each year, as well. Mark's antics on stage with Bill Gaither were an instant hit with Vocal Band audiences and their comedy became the highlight of the evening when the Homecoming tour was born. Mark has been featured on most all of the Gaither Homecoming videos - now numbering more than one hundred - often in the co-hosting role with Bill.
Mark continues to travel across the country with pianist Stan Whitmire. During these concerts, Mark shares his exciting and revitalized message of God's love and grace. In January 2011, Mark released his new DVD called “Mark Lowry: Unplugged & Unplanned” which goes behind the scenes and explores Mark’s favorite experiences from the road.